![]() This can increase the risk of muscle breakdown, liver damage, and even kidney failure. No differences between group in weight, blood pressure, or lipids were. Grapefruit juice can cause that statin to stay in your body much longer, and the drug can build up. Following a 3-week washout diet low in bioactive-rich fruits and vegetables, participants were randomized to either the control diet (n 32) or daily grapefruit (n 42) in the amount of one half of a fresh Rio-Red grapefruit with each meal (3× daily) for 6 weeks. Food and Chemical Toxicology 1993 (31)5:331-5. With some statins, drinking grapefruit juice, or eating grapefruit, is a bad idea. How often are blood tests needed while taking a statin Do statins cause diabetes or memory loss What about drinking alcohol or grapefruit juice while. Journal of Food and Drug Analysis 2017 (25) 1:71-83. It is not as common as other statins because studies have not been done to see if it can lower the risk of heart attack or stroke. Chemistry and health effects of furanocoumarins in grapefruit. Livalo (pitavastatin) helps lower cholesterol and triglyceride (fat) levels. Grapefruit juice and any grapefruit products should be avoided, as should large quantities of limes or lime peel, although small amounts (such as a twist of lime in a drink) are unlikely to cause a significant interaction. Out of all the statins, atorvastatin (Lipitor), simvastatin (Zocor), and lovastatin (Altoprev) have the strongest interaction with grapefruit, and this is likely to be true for other citrus. Unfortunately, in humans, furanocoumarins block one of the main liver enzymes involved in the metabolism of some statins, called CYP3A4, which could lead to increased blood levels of the interacting drug, leading to more severe side effects, including muscle pain. This can raise your risk of side effects, like muscle pain or weakness. ![]() Limes, lemons, and bergamot also contain bergamottin, with limes reported to contain the highest amount, especially peel. Grapefruit and grapefruit juice can increase the amount of atorvastatin in the body. Research has previously identified bergamottin as the main statin-interacting substance in grapefruit. The major furanocoumarins found in grapefruit include bergamottin, epoxybergamottin, and 6′,7′-dihydroxybergamottin. ![]() Grapefruit, limes, and other citrus fruits contain furanocoumarins, which are compounds that help protect the fruit from certain insects and infections. There just hasn't been as much research published regarding how other types of citrus (apart from grapefruit) interact with statins. Limes, pomegranates, pomelos, and Seville oranges can also interact with some medications, including statins such as atorvastatin.
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